The Midden Trail is a mash up of The Oregon Trail and the Dungeons and Dragons campaign I am currently playing in. You choose your party of halfings and set off in search of a new home. On the way you will encounter random obstacles and have to manage your addiction of a fake drug called Green Stone.
This game was made purely to make the players in my Dungeons and Dragons campaign laugh.
Reskinning a game, but with a different story is a great way to create new mechanics. Every games doesn't need to come from scratch. Sometimes it's better to start with something established and then make a fundamental change to it and see where it takes you.